Dr. Madhusudan Purohit

Name: Dr. Madhusudan Purohit
Present Designation: Professor
Department: Pharmaceutical Chemistry
Phone: 0821-2548353
Mobile: +91 9886698475
Fax: 0821-2548359
Mail ID: madhusudhanpurohit@jssuni.edu.in
mnpurohit04@yahoo.com

Educational Qualification

Year	Course	University	Class achieved
2011	PhD in Pharmaceutical Sciences	Rajiv Gandhi University of health Sciences, Karnataka	Awarded
1997	M. Pharm Medicinal Chemsitry Specialization	Gulbarga University, Gulbarga.	First
1995	B. Pharm	Kuvempu University, B.R.project, Shimoga.	First

Highest qualification: PhD in Pharmaceutical Sciences

Area of interest:

Drug Discovery research
Synthetic heterocyclic chemistry
Development of new chemical entities for Tuberculosis and Cancer.

Work History:

Year		College/ Organization	Duration
From	To	College/ Organization	Duration
15-03-2012	to till date	Professor, JSS College of Pharmacy, Mysore.	1 Year and 1 Month
17-06-2006	14-03-2012	Assistant Professor, JSS College of Pharmacy, Mysore.	5 Years 9 Months
07-02-2000	16-06-2006	Lecturer, JSS College of Pharmacy, Mysore.	6 Years 4 Months
16-09-1997	31-01-2000	Lecturer, SCS College of Pharmacy, Harapanahalli.	2 Years 4 Months

Subjects taught

Under Graduate	Post Graduate
B.Pharm	Pharm.D
Medicinal Chemistry Instrumental Methods of Analysis	Medicinal Chemistry Medicinal Biochemistry	Organic Chemistry

Under Graduate

Post Graduate

B.Pharm

Pharm.D

Medicinal Chemistry

Instrumental Methods of Analysis

Medicinal Chemistry

Medicinal Biochemistry

Organic Chemistry

Experience:

Industry	Academics	Research
-	16 Years	10 years

Publications:

National	International
13	09

Conference/ seminar attended

National	International
03	02

RESEARCH GUIDANCE:

Post Graduate	Ph.D
13 (12 completed, 1 ongoing)	-

Member of professional bodies

Name of the Professional body	Registration No.	Registration Date
APTI	KA/LM-183	-
KSPC	25708	-

Reviewer of Joural/s

Medicinal Chemistry Research
Mini Reviews in medicinal chemistry
International J of Pharmacy and Pharmaceutical Sciences
International Journal of Health & Allied Sciences,
Journal of Advanced Pharmaceutical Technology & Research

More details

Publications:

National Publications: 13

M.N. Purohit, G.V.Pujar and Y.C.Mayur. Bisphosphonates in bone metastasis –an overview. Indian Journal of Pharmaceutical Education and Research. 2005;39(1): 14-20.
Madhusudan.N.Purohit, Gurubasavaraj.V.Pujar, K.V. Manohar, R.H.Udupi and G.S.Vijayakumar. Synthesis and antimicrobial activity of bis- [4-substituted-5-mercapto triazol] butane. Indian Journal of Heterocyclic Chemistry. 2006;16 (3): 93-94.
Gurubasavaraj.V.Pujar., K.V.Manohar., R.H.Udupi., M.N.Purohit and M.J.N.Chandrasekar. Synthesis and antimicrobial activity of 4-substituted-5-mercapto 3-carboxamido triazoles. Indian Journal of Heterocyclic Chemistry. 2006;16 (3): 69-70.
M.N.Purohit, Kunal Choukshi, G.V.Pujar, Y.C.Mayur, S.M.Shantakumar. Synthesis and antibacterial activity of 5 (5'-substituted 1, 3, 4-oxadiazol- 2'-yl) dihydropyrimidinone derivatives. Indian Journal of Heterocyclic Chemistry. 2007; 16 (2): 349-352.
M.N.Purohit, Sharad Mohan, Kunal Chokshi, G.V.Pujar. UV-Spectrophotometric estimation of Nabumetone. The Pharma Review. 2007; 155-156.
Gurubasavaraj V.Pujar, C.Synesh, Madhusudan Purohit, N.Srinivasalu and R.H.Udupi., Synthesis, anticonvulsant and anti bacterial activities of some novel pyrazolines derived from benzoxazole and benzimidazoles. Indian Journal of Heterocyclic Chemistry. 2008;17 (2): 387-388.
Madhusudan. N. Purohit, Bhavya.K, Gurubasavaraj. V. Pujar, Synthesis and Biological Activities of Schiff Bases and Mannich Bases derived from 4-aryl dihydropyrimidinones. Journal of Pharmacy and Chemistr. 2009; 3(1): 1-3.
Gurubasavaraj V.Pujar, Madhusudan Purohit and C.Synesh, Synthesis and pharmacological activities of 1,2,4-triazol-3-yl thiols and related systems. Indian Journal of Heterocyclic Chemistry. 2009; 19 (4): 171-174.
Gurubasavaraj V.Pujar, K.Aparna, Madhusudan Purohit et al., Synthesis, hypoglycemic and antibacterial activity of some novel 4-thiazolidinones. Indian Journal of Heterocyclic Chemistr. 2009; 19 (4): 197-198.
Madhusudan Purohit, K.Bhavya and G.V.Pujar. Chemistry and Biological Activity of Biginelli Type Dihydropyrimidinones - A Brief Review. Indian Drugs. 2011; 48: 7-18.
Gurubasavaraj V.Pujar and Madhusudan Purohit. Synthesis, anticonvulsant activity of some novel 1,2,4-triazol-3-yl-thioacetohydrazides derived from benzimidazole and benzoxazole. Journal of Pharmacy and Chemistry. 2011; 4(4): 132-135.
Saugandha Das, M.N. Purohit, Manan Patel and H.G. Shivakumar, Nicotine addiction – quitting for good. Pharma Times. 2012; 44 (6): 13-19.
Sandeep Reddy K, Madhusudan N. Purohit, G.V.Pujar. Synthesis and pharmacological activity of some novel bis-heterocycles encompassing pyrrole. International Journal of Pharmacy and Pharmaceutical Sciences. 2012, 4 (5): 153-157.

International Publications: 09

Y.C.Mayur, Osman Ahmed,VVRS Prasad, M.N.Purohit, N.Srinivasulu and S.M. Shanta Kumar Synthesis of 2-methyl N10 substituted acridones as selective inhibitors of multidrug resisistance (MDR)associated protein in cancer cells., Medicinal Chemistry, 2008, 4(5), 457-465.
B.M Gurupadayya, Madhusudan Purohit and Anandkumar Tengli, Simultaneous estimation of atorvastatin calcium, glimeperide and metformin hydrochloride in tablet formulation by RP-HPLC method. Acta Pharmaceutica Sciencia, 2009, 51,231-235
Gurupadayya.V Bannimath, Madhusudan N. Purohit and Gurubasavaraj.V. Pujar, Determination of ketoprofen in tablet dosage form by gas-Liquid chromatography. World Journal of Chemistry, 2010, 5(1), 67-70
Madhusudan Purohit, Yergeri C. Mayur. Synthesis, in vitro cytotoxicity, and anti-microbial studies of 1,4-bis(4-substituted-5-mercapto-1,2,4-triazol-3-yl)butanes. Medicinal Chemistry Research, 2012, Volume 21, Issue 2, pp 174-184. DOI 10.1007/s00044-010-9517-9
20. Madhusudan Purohit, V.V.S. Rajendra Prasad and Yergeri.C. Mayur. Synthesis and Cytotoxicity of Bis-1,3,4-Oxadiazoles and Bis-Pyrazoles derived from 1,4-Bis[5-Thio-4-Substituted-1,2,4-Triazol-3-Yl]-Butane and their DNA Binding. Archiv der Pharmazie - Chemistry in Life Science. 2011, 11, 248-254. DOI 10.1002/ardp.201000177
21. B. M. Gurupadayya, Ch. Sambireddy, M. N. Purohit, and G. V. Pujar. Synthesis and Pharmacological Evaluation of 7-chloro-6-fluoro-2- (5-aminooxazol/thiazol-2-aryldenylamino)-benzo(1,3)thiazoles Journal of Scientific Research. 2011, 3 (1), 121-128. DOI. 10.3329/jsr.v3i1.6166
Madhusudan N. Purohit, Kuppusamy Pnajamurthy, Santhini Elango, Karteek Hebbar, Yergeri C. Mayur and Sathees C. Raghavan. In-Vitro Cytotoxicity and Cell Cycle Analysis of Two Novel bis-1,2, 4-triazole derivatives: 1,4-bis[5-(5-mercapto-1,3,4-oxadiazol-2-yl-methyl)-thio-4-(p-tolyl)-1,2,4-triazol-3-yl]-butane (MNP-14) and 1,4-bis[5-(carbethoxy-methyl)-thio-4-(pethoxyphenyl)-1,2,4-triazol-3-yl]-butane (MNP-16). Nucleosides, Nucleotides and Nucleic Acids, 2011, 30(11), 873-885. Doi: 10.1080/15257770.2011.608395
P. T.Pudota, R. Shurpali, M. Purohit, G.V. Pujar. Synthesis, in vitro antimicrobial and cytotoxic activities of some novel bis- 1, 3, 4-oxadiazoles. Journal of Applied Chemical Research, 2012, 7, 1, 7-18.
Rohit Singh. Gurubasavaraj V. Pujar, Madhusudan N. Purohit. V. M. Chandrashekar. Synthesis, in vitro cytotoxicity, and antibacterial studies of new asymmetric bis-1,2,4-triazoles. Medicinal Chemistry Research, 2013, 22(5), 2163-21732012, DOI 10.1007/s00044-012-0209-5.

Conference Attended: 05

National	International
11th APTI convention NIMHANS, Bangalore, 01-09-2006 to 03-09-2006 61st Indian Pharmaceutical Congress, Ahmedabad, 17th to 19th December, 2009. 15th APTI-convention Hyderabad, 02-11-2010 to 03-11-2010	International Conference on Health Sciences, Mysore, 25th and 26h February 2005. Indo-US symposium on Frontiers in Medicianl Chemistry and Drug Discovery- Molecule to Medicine- held at JSS University, Mysore during 21st -23rd April 2011. (Awarded Best Poster Prize).

National

International

11th APTI convention NIMHANS, Bangalore, 01-09-2006 to 03-09-2006
61st Indian Pharmaceutical Congress, Ahmedabad, 17th to 19th December, 2009.
15th APTI-convention Hyderabad, 02-11-2010 to 03-11-2010

International Conference on Health Sciences, Mysore, 25th and 26h February 2005.
Indo-US symposium on Frontiers in Medicianl Chemistry and Drug Discovery- Molecule to Medicine- held at JSS University, Mysore during 21st -23rd April 2011. (Awarded Best Poster Prize).

Name of the conference/ seminar and place	Dates	Title of paper presented	Author/s
11th APTI convention during held at NIMHANS, Bangalore	01-09-2006 to 03-09-2006	Synthesis and anti microbial activities of certain novel dihydro pyrimidines /Poster	Madhusudan Purohit, Kunal Choukshi and Sharad Mohan
Indian Pharmaceutical Congress, Ahmedabad,	17th to 19th December, 2009	Synthesis and in vitro antimicrobial and cytotoxic activities of some novel bis- heterocycles /Poster	Madhusudan Purohit and Y.C. Mayur
15th APTI-convention, held at Hyderabad.	02-11-2010 to 03-11-2010	Synthesis and cytotoxicity of certain bis-1,3,4-oxadiazoles and bis-pyrazoles / Poster	Madhusudan Purohit, Yergeri.C. Mayur, Chandrashekar V.M.
Indo-US symposium on Frontiers in Medicianl Chemistry and Drug Discovery- Molecule to Medicine- held at JSS University, Mysore	21-04 -2011 to 23-04-2011	In vitro cytotoxicity and cell cycle analysis of novel bis-1, 2, 4-triazole derivatives./ Poster	Madhusudan N. Purohit, Yergeri C. Mayur

Awards and Achievements:

Secured fourth rank in B.Pharm
Qualified in GATE-1996
Won Best Paper award from IJPER
Won Best poster in Indo-US symposium on Frontiers in Medicianl Chemistry

RESEARCH GUIDANCE:

Post Graduate

Academic year	Name of the student	Dissertation Title
2006-07	Mr. Chokshi Kunal	Synthesis, anticonvulsant and antimicrobial activity of some novel triazoles and oxadiazoles
2006-07	Mr. Sharad Mohan	Synthesis and in vitro antispasmodic activity of some esters of benzophenone.
2007-08	Ms. Bhavya K	Synthesis and analgesic and anti inflammatory activity of novel dihydropyrimidines.
2008-09	Mr. SambiReddy Ch (Co-guide)	Synthesis in vitro anthelmintic and antimicrobial activities of some novel heterocycles derived from fluorobenzothizole
2008-09	Ms. Aparna K (Co-guide)	Synthesis and characterization of certain thiazoldinones as possible hypoglycemic agents
2010-11	Mr. Mihir Trivedi	Synthesis and characterization of few quinazoline derivatives as possible anti-inflammatory agents
2010-11	Mr. Raghunandan S	Synthesis and in vitro cytotoxic activity evaluation of novel bi-heterocyclic systems.
2010-11	Mr.Sandeep Reddy	Synthesis and biological activity of certain 1,2,4-triazole derivatives.
2011-12	Ms.Veena Jonna	Synthesis and in vitro cytotoxicity study of certain quinazoles
2011-12	Mr.Shafiqula Islam	Synthesis and biological activity of certain azoles
2012-13	Ms. Sravani K	Synthesis and characterization of INH analogues as anti TB agents

Research Projects:

Title of the project	Sponsoring agency	Investigator/s	Cost (In Lakhs)	Year of start	Duration	Status
Design and development of novel mycobacterial enoyl CoA reductase (inhA) inhibitors as anti TB agents	DBT	Dr. G.V.Pujar Dr. M.N.Purohit	23.5	2012	3 years	ongoing

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